van Kooyk, Yvette

Amsterdam | Netherlands

van Kooyk, Yvette

Amsterdam | Netherlands
Navn: Yvette van Kooyk PhD
Affiliation: Chair of Department
VUMC Director Amsterdam Infection&Immunity Institute
Dept. Of Molecular Cell Biology and Immunology (MCBI)
Vumc

Prof.dr.Yvette van Kooyk is head of the department Molecular Cell Biology and Immunology at the VU University Medical Center in Amsterdam, the Netherlands that consists of 120 scientist that work in the field of cancer immunology, mucosal immunology, neuro immunology and dermatology. She did her PhD training at the Netherlands Cancer Institute (1989-1993) in the field of transplantation immunology revealing pioneering molecular mechanisms that regulate immune cell adhesion through integrin activation. From her postdoc-to associate professor at RadboudUMC (1994-2000), and training at Genentech, US, she focussed her research on cell adhesion and Dendritic cells in inflammatory immune processes.In 2000, she discovered the, innate receptor DC-SIGN a C-type lectin on Dendritic cells, playing a crucial role in HIV recognition and cellular interactions through the recognition of glycan structures. This discovery set the stage of a whole new field that led to new concepts on pathogen interactions through C-type lectin receptor, that modify Dendritic cell responses.  In 2001 she moved to the VUmc, Amsterdam and became professor molecular  cell biology and immunology. Van Kooyk’s research team is working on dendritic cell (DC) mediated immune responses guided by glycosylation. Her work is focused on innate immune responses and cellular communication driven by modified glycoproteins/lipids in cancer and autoimmunity such as MS. Central in her work is the development of new glycan modified cancer vaccines targeting  skin resident antigens presenting cells  such as DC. Her research is aimed to discover of glycan imposed regulatory immune imprinting by inflamed tissue and tumor microenvironment. She studies these questions in in-vivo mouse tumor models such as well as EAE models and human in-vitro models such as skin model, tumor and MS tissues and complex 3D culture models to identify  cellular communication at omics level in the context of tissue alterations.

She was  recently awarded the SPINOZA premium, and has various NWO grants (PIONIER-ASPASIA-TOP), EU grants (ERC Advanced-Eurostars) and the van Loghem award for life time achievements in field of Immunology, and is a member of the Royal Netherlands Academy of Sciences (KNAW). She published more than 250 scientific papers in well recognized journals (Cell, Nature, Nature Immunology, PNAS, JEM) and supervised 29 PhD students. She is inventor of 6 patents and is Chief Scientific Officer of the start-up company DC4U.

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