Name: Jack van Horssen PhD
Affiliation: Program Leader Bachelor Medicine
Vumc School of Medical Sciences
Department of Molecular Cell Biology and Immunology
Throughout my scientific career I have been interested in understanding the pathogenetic basis of neurodegenerative disorders. I received myPh.D. in 2005 fromthe Radboud University Nijmegen, where he was involved in Alzheimer’s disease research at the department of Pathology. Currently, I amappointed as an associate professor at the Department of Molecular Cell Biology and Immunology of the VU University Medical Center Amsterdam, the Netherlands and a visiting Professor at the Biomedical Research Institute of the Hasselt University, Belgium. Throughout my scientific career I have been interested in understanding the pathogenetic basis of neurodegenerative disorders. My research line is focused on the identification of pathogenic processes and molecular pathways underlying multiple sclerosis (MS) disease progression. We particularly focus on understanding the pathological key events that are involved in inflammation-driven neurodegeneration. Our group has shown that impaired mitochondrial metabolism and enhanced reactive oxygen species (ROS) production play a central role in MS pathology and we are exploring the potential of antioxidant and mitochondrial protection to counteract oxidative stress and improve mitochondrial function. The approach we use is to assemble information obtained from neuropathological examination of MS brain tissue and translate these findings into experimental in vitro and in vivo models and vice versa.