Epigenetic regulation of microglia phenotypes
Microglia are the tissue resident macrophages of the CNS with innate immune functions. Microglia are a fairly long-lived self-sustained cell population with limited turnover. Like other innate immune cells, microglia have the potential to serve as a memory for past inflammatory events, similar to endotoxin tolerance and trained immunity in macrophages. Here we performed genome-wide RNA expression profiling, ChIP- and ATAC-sequencing approaches to delineate the epigenetic underpinnings of microglia innate immune memory, and endotoxin tolerance and enhance immune activation in particular.