How immunotherapies work in MS
Multiple sclerosis is one of the few neuroimmunological conditions where there are approved therapies. Although, genetics, pathology and animal models can provide clues, response to therapy is a key experiment in understanding the biology of the human condition. Animal models have provided a focus on T cell biology that has led to development of a large number of different immunotherapies. We will explore the complexity of their purported therapeutic mechanisms and balance this with the clinical experience, notably following the adoption of B cells therapies to form a hypothesis that incorporates aetiology, biology, pathology and response to therapy that can challenge simple acceptance of dogma and perhaps make the biology of MS simpler to understand.