Dr. Renzo Mancuso PhD

MIND lab,
VIB-Center for Molecular Neurology,
Antwerpen | Belgium

I obtained my PhD in Neuroscience at the Autonomous University of Barcelona in the laboratory of Prof. Xavier Navarro at the group of Neuroplasticity and Regeneration. I performed my postdoctoral trainings in the laboratories of Prof. V. Hugh Perry at the University of Southampton (UK), and Prof. Bart De Strooper at the VIBKU Leuven Center for Brain & Disease Research in Belgium. My scientific work is focused on the role of microglia in Alzheimer’s disease, linking human genetics with microglia function in iPSC-derived microglia and xenotransplantation models. My major findings are elucidating the detrimental role of microglia in the aggregation of tau and tau-induced cell death, the development and application of microglia humanized models for the study of genotype-phenotype interactions and several aspects of human microglial biology, in vivo, in neurodegenerative diseases. I am currently group leader at the VIB-Center for Molecular Neurology where I aim to dissect the role of microglia and neuroinflammation in Alzheimer’s and Frontotemporal dementia, using cellular systems to uncover major phenotypic modifications in microglia and building up from there into more complex in vivo chimeric models, and human primary samples. Therefore, I am well suited to lead the work proposed in this project.