Day 1
16 Lug 2019
8:45 - 9:30

REGISTRATION AND COFFEE

9:30 - 12:55

Morning session | Technology

Amor, Sandra
Willison, Hugh

Welcome

Amor, Sandra
SPEECH

Expert session: multiple sclerosis

de Jong, Brigit A.
SPEECH

Brain Banking

Huitinga, Inge
12:25 - 12:55

LUNCH AND POSTER PRESENTATIONS

POSTER

023 – CSF1R stimulation promotes increased neuroprotection by CD11c+ microglia in EAE

Benmamar-Badel Anouk (1, 2)
Department of Neurobiology Research, Institute for Molecular Medicine, University of Southern Denmark, Odense, Denmark (1) - Department of Neurology, Slagelse Hospital, Slagelse, Denmark (2)
POSTER

008 – Surrogate markers of central nervous system inflammation in cerebrospinal fluid in autoimmune encephalitis and psychosis

Jocelyn X Jiang (1, 2, 4)
Department of Immunopathology, New South Wales Health Pathology-ICPMR, Westmead Hospital, Westmead NSW Australia (1) - Department Clinical Immunology Westmead Hospital, Westmead NSW Australia (2) - Sydney Medical School, University of Sydney, Sydney NSW Australia (4)
POSTER

020 – ADAPTIVE NATURAL KILLER CELLS IN MULTIPLE SCLEROSIS

Bernat Bertran Recasens (1)
Hospital del Mar, Neurology Department, Barcelona, Spain (1)
POSTER

025 – Circulating miR-191-5p, miR-223-3p, miR-24-3p and miR-128-3p in sera of MS patients, longitudinal study

Julia Vistbakka (1)
Tampere University, Medicine and Life Sciences, Tampere, Finland (1)
POSTER

034 – Recurrent aseptic meningoencephalitis as CNS manifestation of cryopyrin-associated syndrome in an adult patient heterozygous for the Q703K variant in exon 3 of the NLRP3 gene

Miriam Schlüter (1)
Institute of Clinical Neuroimmunology, University Hospital, Ludwig-Maximillian University, Munich, Germany (1)
POSTER

026 – IgD-CD27- double negative B cells of multiple sclerosis patients are mature memory cells that can migrate towards pro-inflammatory chemokines

Beckers Lien (1)
Hasselt University, Biomedical Research Institute and Transnationale Universiteit Limburg, School of Life Sciences, Hasselt, Belgium (1)
13:00 - 17:30

Afternoon session | Technology

Bajramovic, Jeffrey
Woodroofe, Nicola
SPEECH

Tracking neuroinflammation in the living human brain

Alessandro Colasanti
Brighton & Sussex Medical School, Sussex University
Colasanti, Alessandro
SPEECH

Epigenetic regulation of microglia phenotypes

Bart J.L. Eggen
Department of Biomedical Sciences of Cells & Systems, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
Eggen, Bart J. L.
15:00 - 15:30

COFFEE & TEA

SPEECH

In vivo microscopy approaches to CNS inflammation

Martin Kerschensteiner, MD
Institute of Clinical Neuroimmunology, Ludwig-Maximilians University Munich, Germany
Kerschensteiner, Martin
16:30 - 17:30

Historical People and Landmarks in Neuroimmunology

17:30 - 18:30

WELCOME DRINKS AND SNACKS

Day 2
17 Lug 2019
09:00 - 12:55

Morning Session | Immunology

9:00 - 10:00

Pecha Kucka presentations

Baker, David
Bradl, Monika
ORAL

003 – Macrophages Regulate Schwann Cell Maturation after Nerve Injury

Jo Anne Stratton (1)
Hotchkiss Brain Institute, 3330 Hospital drive NW, University of Calgary, HMRB 403b Foothills Campus, Calgary, Canada (1) - Hotchkiss Brain Institute, University of Calgary, Calgary, Canada (2)
ORAL

015 – Rescuing over-activated microglia by acetaminophen treatment restores cognitive performance in the Dp(16) mouse model of Down Syndrome

Bruno Pinto (1, 2)
BIO@SNS, Scuola Normale Superiore, Piazza dei Cavalieri 7, 56126. Pisa (1) - Local Micro-environment and Brain Development Laboratory, Istituto Italiano di Tecnologia, via Morego 30, 16163 Genova (2)
ORAL

002 – The neuroprotective effects of calpastatin on axonal integrity in a murine model of Guillian-Barre_ Syndrome

Hannah Bialic (1)
University of Glasgow, Institute of Infection, Immunity, and Inflammation, Glasgow, United Kingdom (1)
ORAL

014 – A quantitative neuropathological assessment of translocator protein expression in multiple sclerosis

Erik Nutma (1)
Department of Pathology, Amsterdam UMC, Location VUmc, The Netherlands (1)
ORAL

005 – Fatty acid desaturation impairs the reparative features of phagocytes in the central nervous system

Elien Grajchen (1#)
Department of Neuroimmunology and Biochemistry, Biomedical Research Institute, Hasselt University, Diepenbeek, Belgium (1)
SPEECH

Expert session: Guillain – Barré Syndrome

Patricia H. Blomkwist-Markens and Hugh Willison
University of Glasgow, South Glasgow Hospitals University, NHS Diagnostic Neuroimmunology Laboratory, Southern General Hospital
Willison, Hugh
11:00 - 11:15

COFFEE & TEA

SPEECH

Neural stem cells in neuroimmunology: from brain homesotasis to therapy

Gianvito Martino MD
Neuroimmunology Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy
Martino, Gianvito
12:15 - 12:55

LUNCH AND POSTER PRESENTATIONS

POSTER

006 – Neuroinflammation in Metachromatic Leukodystrophy: A missing key factor in treating a lysosomal storage disorder?

Shanice Beerepoot (1, 2)
Department of Child Neurology, Emma Children’s Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam, and Amsterdam Neuroscience, De Boelelaan 1117, Amsterdam, the Netherlands (1) - Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, the Netherlands (2)
POSTER

030 – Probenecid and its various targets in the treatment of multiple sclerosis: A single player or an orchestra of all?

Lea Müller (1)
Institute of Anatomy, Saarland University, Homburg, Germany (1)
POSTER

024 – Investigating the interaction of Th17 cells and B cells in initiation and progression of EAE

Anna Kolz (1)
Institute of Clinical Neuroimmunology, Ludwig-Maximilians-Universität München, Munich, Germany (1)
POSTER

037 – Microglial Extracellular Vesicles as Therapeutic Vector for Neuroinflammation

Giulia Marostica (1)
San Raffaele Scientific Institute, Clinical Neuroimmunology Unit, MIlan, Italy (1)
POSTER

019 – Cortical microglia in progressive MS acquire a unique phenotype in response to chronic meningeal inflammation

Lynn van Olst (1)
Amsterdam UMC, Molecular Cell Biology and Immunology, Amsterdam, Netherlands (1)
POSTER

016 – Validation of MOG cell-based assay and clinical features of MOG-positive patients in a Korean cohort

Woo Kyo Jeong, MD (1, 2)
Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea (1) - Neuroscience Center, Samsung Medical Center, Seoul, Korea (2)
13:00 - 17:15

Afternoon session | Immunology

Owens, Trevor
van der Valk, Paul
SPEECH

Glycocode changes in tissues of cancer and autoinflammation, resolution of inflammation, novel immune check-point

Yvette van Kooyk* - Juan Martin Illaregui, Ernesto Rodriguez, Kari Brown, Sjoerd T.T. Schetters, Gijs Kooij,Sandra van Vliet, Juan J. Garcia-Vallejo, Elga de Vries
Department of Molecular Cell Biology and Immunology, Department of Surgery, Department of Medical Oncology, Amsterdam UMC, VU University medical Centre, Amsterdam UMC, de Boelelaan 1108, 1081HZ Amsterdam, the Netherlands
van Kooyk, Yvette
SPEECH

Modulation of immune responses during pregnancy in multiple sclerosis

Manuel Friese
Professor of Neuroimmunology and Director of the Institute of Neuroimmunology and Multiple Sclerosis (INIMS) University Medical Center Hamburg-Eppendorf
Friese, Manuel
14:40 - 15:10

COFFEE & TEA

SPEECH

Paper analysis

David Baker (1) - Nichola Woodroofe (2)
Neuroimmunology Unit, Blizard Institute Barts and the London School of Medicine and Dentistry Queen Mary, University of London (1) Head, Biomolecular Sciences Research Centre, Sheffield Hallam University (2)
Baker, David
Woodroofe, Nicola
16:30 - 17:15

Historical People and Landmarks in Neuroimmunology

Day 3
18 Lug 2019
09:00 - 13:10

Morning Session | Neurology

9:00 - 10:00

Pecha Kucka presentations

de Jong, Brigit A.
Martinez, Pilar
ORAL

029 – PD-L1 and PD-L2 expression in blood immune cells and cerebrospinal fluid extracellular vesicles in Multiple Sclerosis. ThereÕs room for novel therapeutic approaches.

Tommaso Croese (1)
Institute of Experimental Neurology (INSPE), Clinical Neuroimmunology Unit, Milan, Italy (1)
ORAL

007 – A bioinformatics approach to study microglial morphology and surveillance in CNS diseases

Ilias Roufagalas (1)
Hellenic Pasteur Institute, Laboratory Of Molecular Genetics, Athens, Greece (1)
ORAL

038 – Soluble TNF inhibits phagocytosis of myelin debris by mouse macrophage and microglia, and remyelination of demyelinated lesions

Athina Boutou (1)
Hellenic Pasteur Institute, Labortatory of Molecular Genetics, Department of Immunology, Athens, Greece (1)
ORAL

032 – Development of drug-screening platform with murine and human neurons for multiple sclerosis (MS) to identify compounds with a neuroprotective potential and assess disease-specific dysfunctions.

Svetlana Bezukladova (1)
San Raffaele Scientific Institute, Division of Neuroscience - INSPE - Institute of Experimental Neurology, Neuroimmunology Unit, Milano, Italy (1)
ORAL

047 – RNA-transcriptome guided optimization of in vitro culture conditions for adult primary microglia

Raissa Timmerman (1)
Alternatives Unit, Biomedical Primate Research Centre, Lange Kleiweg 161, 2288 GJ Rijswijk, The Netherlands (1)
SPEECH

Autoimmune diseases of the neuromuscular synapse

Jan J.G.M. Verschuuren
Department of Neurology, Leiden University Medical Centre, the Netherlands
Verschuuren, Jan
10:40 - 11:00

COFFEE & TEA

SPEECH

Lymphatic drainage of the brain. Is there a “glymphatic” system?

Roy O Weller, MD PhD - Roxana O Carare, MD PhD
Faculty of Medicine, University of Southampton, UK
Weller, Roy O.
SPEECH

Identifying remyelinating agents for drug discovery

Lynette Foo
Scientist, Neuroimmunology & Neurodegeneration Section Neuroscience Discovery, NORD DTA Roche Pharmaceutical Research and Early Development - Roche Innovation Center Basel
Foo, Lynette
12:40 - 13:00

LUNCH AND POSTER PRESENTATIONS

POSTER

017 – Utility of CXCL-8,-10,-13 and CCL-2 chemokines in patients with isolated optic neuritis or transverse myelitis

Hana Nohejlova (1, 2)
Department of Paediatric Neurology, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital (1) - Department of Neurology, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital (2)
POSTER

011 – The role of CD20+ T cells in induced and spontaneous EAE models

Jasmin Ochs (1)
Department of Neuropathology, University medical center, Georg-August University Gšttingen (1)
POSTER

004 – Antibody repertoire and antigen recognition of B lineage cells in a unique case of human autoimmune encephalitis

Manuela Paunovic (1)
Department of Neuroimmunology, Center for Brain Research, Medical University of Vienna, Austria (1)
POSTER

021 – Investigating the role of cytokine-producing B cells in initiation and regulation of EAE

Anna Sophie Thomann (1)
Institute of Clinical Neuroimmunology, University Hospital and Biomedical Center, Ludwig-Maximilians-UniversitŠt MŸnchen, Munich, Germany (1)
13:15 - 17:30

Afternoon session | Neurology

13:15 - 16:30

Practical Course

16:30 - 17:30

Historical People and Landmarks in Neuroimmunology

Bajramovic, Jeffrey
Nutma, Erik
18:30 - Till late

BARBEQUE DINNER WITH LIVE DJ

Day 4
19 Lug 2019
09:00 - 16:45

Morning Session | Therapies

9:00 - 10:00

Pecha Kucka presentations

Owens, Trevor
van Horssen, Jack
ORAL

009 – The role of autoreactive antibodies in initiation and propagation of central nervous system demyelinating disorders

Marie Freier (1)
Department of Neuropathology, University Medical Centre, Georg August University Gšttingen (1)
ORAL

028 – Transcriptional analysis of peripheral monocytes upon fingolimod treatment in Relapsing Remitting Multiple Sclerosis patients

Giacomo Sferruzza (1)
San Raffaele Scientific Institute, Neurology, Milano, Italy (1)
ORAL

010 – Chitinase 3-like 1 as a biomarker of multiple sclerosis progression

Laura Cubas-Nuñez (1+)
Multiple Sclerosis and Neural Regeneration Research Group. Health Research Institute La Fe. Avda. Fernando Abril Martorell, 102. 46026 Valncia (1) - Central Neuroimmmunology Unit. Hospital Universitari i Politcnic La Fe. Avda. Fernando Abril Martorell, 106. 46026 Valncia (2) - Department of Neuroimmunology (Center for Brain Research). Spitalgasse 4 Vienna (Austria) (3) - + Equal contribution
ORAL

018 – TGFB1-mediated gliosis in multiple sclerosis spinal cords is favored by the physiological expression of regionalization homeobox genes and the age-dependent decline in androgen receptor ligands

Serge Nataf (1)
University Claude Bernard Lyon-1, CarMeN Laboratory, INSERM 1060, INRA 1397, INSA Lyon, Bank of Tissues and Cells, Hospices Civils de Lyon, Lyon, France (1)
ORAL

013 – Muscular Involvement in Lewis Rats with Experimental Neuromyelitis Optica

Magdalini Nigritinou (1)
Center of Brain Research, Neuroimmunology Department, Medical University of Vienna, Vienna, Austria (1)
SPEECH

Autoimmunity and/or Psychiatry

Jocelyn X Jiang (1,2) - David A Brown (1,2)
Department of Clinical Immunology and Immunopathology, ICPMR, Westmead Hospital, NSW (1) - University of Sydney, NSW (2)
Jiang, Jocelyn
10:45 - 11:00

COFFEE & TEA

SPEECH

How immunotherapies work in MS

David Baker
Neuroimmunology Unit, Blizard Institute Barts and the London School of Medicine and Dentistry Queen Mary University of London
Baker, David
12:50 - 13:10

LUNCH AND POSTER PRESENTATIONS

POSTER

036 – THE EXPRESSION OF NGF AND TRKA IN IFLAMMATORY LOCI IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS

Nickoleta Delivanoglou (1)
Laboratory of Experimental Neurology and Neuroimmunology, AHEPA University Hospital, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece(1)
POSTER

027 – Isolation of exosomes from human plasma: comparison of size exclusion chromatography columns with ultracentrifugation.

Stefano Gelibter (1)
San Raffaele Hospital, Clinical neuroimmunology Unit,Institute of Experimental Neurology (INSPE), MILANO, Italy (1)
POSTER

046 – THE ROLE OF GAP JUNCTION-DEPENDENT CYTOKINES IN THE EAE MODEL OF MULTIPLE SCLEROSIS

Filippos Stavropoulos
The Cyprus Institute of Neurology and Genetics
SPEECH

How to develop your own CNS drug

Hans van Noort
Business Unit Manager MicroSafe Laboratories
van Noort, Hans

Debate

Owens, Trevor
Woodroofe, Nicola
15:30 - 15:50

COFFEE & TEA & PROSECCO

Prizes

ESNI COMMITEE